Retinoids Help Normalize KeratinizationAlthough the mechanism by which topical and systemic retinoids help restore acne follicles to a healthy state is unknown, it has been well demonstrated that they normalize keratinization within the infundibular region of the follicle, so that shed follicular cells slough to the surface of the skin rather than clump together and obstruct the pores.After exposure to retinoids, follicular cells actually turn over more rapidly than they would in a pre-acne state.Retinoic acid has a high affinity for the gamma retinoid receptors, which are believed to be integral to the pathogenesis of acne.In addition to their ability to reverse abnormal keratinization within the follicle, the topical retinoids - especially adapalene (Differin®), a naphthoic acid derivative - may have anti-inflammatory properties and thus may address two factors involved in the development of acne.
After the above has been done, the next sould be exfoliating. Use a scrub or facial mask and please, let the product do its work. Don't try to help the product as some people tend to in their zeal cause irritation during this process because they are rough while exfoliating. Just let the product do what it should do. Patience is the key. After exfoliating, you might use a toner to residual dead skin or and or excess cleanser. it is necessary again to use a toner made for your skin type.
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